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مقالات فارسیISIکنفرانسهاژورنالها

Serum Adiponectin and Vaspin levels in Abdominal Obesity and Type ۲ Diabetes Mellitus

محل انتشار: مجله دیابت و چاقی ایران، دوره: 10، شماره: 1
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 63

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1814045

شناسه ملی سند علمی:

JR_IJDO-10-1_004

تاریخ نمایه سازی: 16 آبان 1402

چکیده مقاله:

Abstract Objective: Adiponectin and vaspin are adipocyte-derived proteins and involved in the regulation of glucose metabolism and obesity related disorders. The mechanisms that adipokines might be linked to disturbance of glucose are unclear. Thus, this study investigated the levels of serum adiponectin and vaspin, blood lipid profiles, and abdominal obesity in type ۲ diabetes (T۲DM) patients and controls. Materials and Methods: Frothy T۲DM patients and ۴۰ healthy volunteers matched by age and body mass index (BMI) were enrolled in the study. The levels of serum adiponectin, vaspin, fasting blood glucose (FBG), ۲-hr post prandial (۲hr-PP), and lipid profile were measured in both groups. Anthropometric parameters including BMI, waist circumference (WC) and waist to height ratio (WHR) were measured. Results: Higher levels of vaspin and lower levels of circulating adiponectin were observed in T۲DM patients than in the controls (P-value:۰.۰۰۰۱). In multivariate regression analyses adjusted for age and BMI, serum adiponectin levels showed a significant negative correlation with WC, WHR, FBG and duration of diabetes, and a positive correlation with HDL. While, the vaspin levels were positively correlated with WC, WHR and duration of diabetes in T۲DM patients. In addition, vaspin and adiponectin levels had negative correlation with each other. Conclusion: The findings suggested that the abdominal obesity had the highest relationship with adiponectin and vaspin in diabetic patients.

کلیدواژه ها:

Adiponectin ، Vaspin ، Obesity ، Type ۲ diabetes

نویسندگان

Farzaneh Montazerifar

Pregnancy Health Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Mansour Karajibani

Health Promotion Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Mahmood Ali Keikhaie

Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

Maryam Mohammadi

Student Scientific Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Shaghayegh Hemmat Jouy

Student Scientific Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Maryam Rezaie

Department of Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

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