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مقالات فارسیISIکنفرانسهاژورنالها

The Ratio of Cysteine-Rich Angiogenic Inducer ۶۱ to MicroRNA -۱۵۵ Expression as a Preeclampsia Diagnostic Marker and Predictor of Its Severity

محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 12، شماره: 2
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 53

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لینک ثابت به این مقاله:
https://civilica.com/doc/1863462

شناسه ملی سند علمی:

JR_RBMB-12-2_013

تاریخ نمایه سازی: 4 دی 1402

چکیده مقاله:

Background: Preeclampsia (PE) is a multisystem pregnancy disorder that increases maternal-perinatal morbidity and mortality significantly. MicroRNA-۱۵۵ (miR-۱۵۵) overexpression in the sera of pregnant women has been linked to preeclampsia. Researchers discovered that miR-۱۵۵ acts during pregnancy by down-regulating and reducing the cysteine-rich angiogenic inducer ۶۱ (CYR۶۱), which causes local ischemia as well as oxidative stress. Methods: The level of miR-۱۵۵ expression in all serum samples was quantified using real-time polymerase chain reaction (RT-PCR), and serum CYR۶۱ was measured using enzyme-linked immunosorbent assays. Together with the Cyr-۶۱/miR-۱۵۵ ratio, they were evaluated as biomarkers for PE pathogenesis and severity prediction. Results: MiR-۱۵۵ expression, serum CYR۶۱ levels, and Cyr-۶۱/miR-۱۵۵ ratios were all significantly higher in PE patients compared to the control group. Serum CYR۶۱ levels and the Cyr-۶۱/miR-۱۵۵ ratio differed significantly between mild and severe PE patients. Conclusion: MiR-۱۵۵ expression, serum CYR۶۱ levels, and Cyr-۶۱/miR-۱۵۵ may serve as biomarkers for PE pathogenesis and severity prediction.

کلیدواژه ها:

Biomarker ، Cysteine-Rich Protein ۶۱ ، MicroRNAs ، Pre-Eclampsia.

نویسندگان

Sarah Mamdouh Shoeib

Clinical pathology department, Faculty of Medicine, Tanta University, Egypt.

Doaa Elwy Abdeldaim

Public Health Department, Faculty of Medicine, Tanta University, Tanta.

Shimaa Samir Mashal

Internal Medicine department, Faculty of Medicine, Tanta University, Egypt.

Rowida Raafat Ibrahim

Medical Biochemistry & Molecular Biology Department, Faculty of Medicine, Tanta University, Egypt.

Lamees Mohamed Dawood

Medical Biochemistry & Molecular Biology Department, Faculty of Medicine, Tanta University, Egypt.

Doaa Shatat

Gynecology and Obstetrics Department, Faculty of Medicine, Tanta University, Egypt.

Yasmine Ibrahim El-Masry

Gynecology and Obstetrics Department, Faculty of Medicine, Tanta University, Egypt.

Ahmed Almeldin

Physiology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Radwa Mahamoud El Sharaby

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