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مقالات فارسیISIکنفرانسهاژورنالها

Association of Rs۷۲۱۷۱۸۶ Polymorphism of Arachidonic Acid ۱۵-Lipoxygenase (ALOX۱۵) Gene with Susceptibility to Allergic Rhinitis

محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 12، شماره: 2
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 54

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لینک ثابت به این مقاله:
https://civilica.com/doc/1863468

شناسه ملی سند علمی:

JR_RBMB-12-2_007

تاریخ نمایه سازی: 4 دی 1402

چکیده مقاله:

Background:  Allergicrhinitis (AR) is an inflammatory disorder of the nasal mucosa, caused by exposure to environmental allergens. It is known that ۱۵-lipoxygenase (۱۵-LOX) is involved in the biosynthetic pathways of anti-inflammatory lipid mediators, including resolvins and protectins. Methods: In this study, which was performed on ۱۳۰ AR patients and ۱۳۰ healthy controls, we aimed to investigate the association of susceptibility to AR with two selected single-nucleotide polymorphisms (SNPs), that is, rs۲۶۱۹۱۱۲:A>G and rs۷۲۱۷۱۸۶:C>T, in the intron regions of arachidonic acid ۱۵-LOX (ALOX۱۵) gene, using SNPinfo and Regulome DB tools. Results: The results showed that the CT genotype of rs۷۲۱۷۱۸۶: C>T was significantly associated with the increased risk of AR compared to the CC genotype (P= ۰.۰۳۷, OR=۱.۹۴۳, CI: ۱.۰۳۸-۰.۶۳۸). However, there was no strong evidence of the association of rs۲۶۱۹۱۱۲: A>G with susceptibility to AR (P> ۰.۰۵). Conclusions: The present results indicated that rs۷۲۱۷۱۸۶ polymorphism of ALOX۱۵ gene might be a potential biomarker for susceptibility to AR.

کلیدواژه ها:

Allergic rhinitis ، Arachidonate ۱۵-lipoxygenase ، Immunoresolvents ، Single-nucleotide polymorphism ، Specialized proresolving lipid mediators (SPMs).

نویسندگان

Atefeh Eivazi

Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Bahman Akbari

Department of Biotechnology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Sara Falahi

Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Ali Gorgin Karaji

Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Alireza Rezaiemanesh

Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Seyed Hamid Reza Mortazavi

Department of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Niloofar Daneshfar

Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Farhad Salari

Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

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