Resveratrol Supplement Could Reverse the Effect of Resistance Training on Muscular eMHC and PAX۷ in BALB/C Mice Bearing CT-۲۶ Tumor

Enayatollah Asadmanesh; Maryam Koushki Jahromi; Farhad Daryanoosh; Javad Neamati; Mahdi Samadi

Resveratrol Supplement Could Reverse the Effect of Resistance Training on Muscular eMHC and PAX۷ in BALB/C Mice Bearing CT-۲۶ Tumor

محل انتشار: مجله گزارش بهداشت و درمان، دوره: 5، شماره: 4

سال انتشار: 1398

نوع سند: مقاله ژورنالی

زبان: انگلیسی

مشاهده: 53

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https://civilica.com/doc/1907734

شناسه ملی سند علمی:

JR_RHCA-5-4_004

تاریخ نمایه سازی: 24 بهمن 1402

چکیده مقاله:

Introduction: Although resistance training and resveratrol is recommended as a stimulant for muscle regeneration in healthy subjects their effects on cancer-related cachexia indices are unclear. This study aimed to investigate the effect of a course of resistance training with resveratrol supplement on PAX-۷ and eMHC in Gastrocnemius muscle tissue of mice bearing colon cancer induced cachexia. Methods: This was an experimental study conducted on ۲۰ six-week-old BALB/c mice implanted with CT-۲۶ tumor. The mice were randomly divided into four groups: resistance training, resveratrol, resveratrol with resistance training, and control. The resistance training group performed ۶ weeks of progressive resistance training, the resveratrol group received ۱۰۰ mg/kg resveratrol per day. ۴۸ hours after the last experimental session, the mice were sacrificed and PAX-۷ and eMHC protein levels were measured using ELISA test through specimen taken from gastrocnemius muscles. Statistical test of one way ANOVA was used for data analysis. Results: PAX-۷ level was significantly lower in resveratrol with resistance training group compared to control (P=۰.۰۰۹), resveratrol (P=۰.۰۰۵), and resistance training groups (P=۰.۰۰۲). eMHC was significantly lower in the resistance training group compared to the control (P=۰.۰۸), resistance training, and resveratrol groups (P=۰.۰۰۲). Conclusion: Resistance training was not an appropriate intervention for treating reduced muscular regeneration due to cachexia. However, regarding reducing effect of resveratrol supplementation with resistance training on PAX-۷ level, it may be recommended to improve muscular regeneration.

کلیدواژه ها:

Resistance Training ، Resveratrol ، PAX-۷ ، eMHC ، Cancer ، Cachexia

نویسندگان

Enayatollah Asadmanesh